MagAC therapy for joint pain

Scientific Rationale Behind the Operating Principles of the

Magnetix ArthroCare (MagAC) Device

The starting point is that Magnetix ArthroCare device stimulates higher chondrocyte activity. In order to actually activate such a process, it is necessary to:

1. Work with changing electromagnetic signals, as a permanently repeated similar impulse or stimulus of the cells is quickly perceived as с;

2. Cover the whole sensitivity range of the chondrocytes by an appropriate electromagnetic signals pattern.

Comparison of MagAC
to Standard Joint Therapy

Comparison of MagAC
to Standard Joint Therapy

1. Kraus-Lechner System Coil
This system coil delivers an alternating current magnetic field that generates a sinusoidal waveform. This signal does not conform to what normally takes place in the body because electric activities in all living organisms follow only direct current oriented processes.
2. PEMF -
Pulsed electromagnetic field
PEMF (Pulsed Electromagnetic Fields) therapy uses a constant, direct-current signal, repeated at specific intensities and frequencies throughout treatment. This method, including in vitro cell culture studies, was crucial in developing Magnetix ArthroCare technology by Dr. Richard Markoll.
3. Magnetix ArthroCare

Magnetix ArthroCare represents an evolution of PEMF technology, generating a pure magnetic field with direct current and unidirectional biological frequencies. Its quasi-rectangular waveform delivers alternating pulsed electromagnetic signals, primarily between 10 and 30 Hertz. This indicates its operation at low frequencies and field strengths.

1. Kraus-Lechner System Coil
This system coil delivers an alternating current magnetic field that generates a sinusoidal waveform. This signal does not conform to what normally takes place in the body because electric activities in all living organisms follow only direct current oriented processes.
2. PEMF -
Pulsed electromagnetic field
PEMF (Pulsed Electromagnetic Fields) therapy uses a constant, direct-current signal, repeated at specific intensities and frequencies throughout treatment. This method, including in vitro cell culture studies, was crucial in developing Magnetix ArthroCare technology by Dr. Richard Markoll.
3. Magnetix ArthroCare

Magnetix ArthroCare represents an evolution of PEMF technology, generating a pure magnetic field with direct current and unidirectional biological frequencies. Its quasi-rectangular waveform delivers alternating pulsed electromagnetic signals, primarily between 10 and 30 Hertz. This indicates its operation at low frequencies and field strengths.

Besides the main physical parameters examined here - wave form, field strength and frequency - there are other important characteristic features, such as energy carriers, work cycle, impulse frequency, implementation etc. which are fundamentally different in these three therapy methods.

  • Healthy joint –

    streaming potential

    Movements generate

    • fine electric currents in the joint
    • electrical field of the joint
    • control of the constant preserving and regenerating the cartilage and connective tissues
  • Disturbed

    electrical field

    - Alteration of the electrical field by osteoarthritis or injuries

    - Perturbation in the continued

    cartilage regeneration.

  • MagAC treatment - formation of the electrical field

    - Activation of streaming potentials by Magnetix ArthroCare

    - This signal stimulates the regeneration process in cartilage, tendons and ligaments

  •    Healthy joint –

       streaming potential

    - Movements generate fine electric currents in the joint

    - Electrical field of the joint

    - Control of the constant preserving and regenerating the cartilage and connective tissues

  •    Disturbed

       electrical field

    - Alteration of the electrical field by osteoarthritis or injuries

    - Perturbation in the continued

    cartilage regeneration.

  •   MagAC treatment -

      formation of the

      electrical field

    - Activation of streaming potentials by Magnetix ArthroCare

    - This signal stimulates the regeneration process in cartilage, tendons and ligaments

MagAC supports regeneration

and repair of bone and cartilage tissues

Bone and cartilage tissues have electromagnetic natural bio-potentials which are of crucial importance to the formation and the dynamic functional adaptation of the tissue. Various factors, including electric stimuli such as pulsed electromagnetic fields, can activate the regeneration process. The combined energy parameters of Magnetix ArthroCare, belong to the range also observed in the connective tissue.

Magnetix ArthroCare
has a specific signal pattern:
-Constant changes in intensity, duration and frequency (frequency 1-30 Hz, field strength 0,5-1,5 mT, 5-15 Gauss)
- The signals correspond with the natural physiological body signals
-They activate the self healing process of the body

Magnetix ArthroCare

supports regeneration

and repair of bone and

cartilage tissues

Bone and cartilage tissues have electromagnetic natural bio-potentials which are of crucial importance to the formation and the dynamic functional adaptation of the tissue. Various factors, including electric stimuli such as pulsed electromagnetic fields, can activate the regeneration process. The combined energy parameters of Magnetix ArthroCare, belong to the range also observed in the connective tissue.

Magnetix ArthroCare
has a specific signal pattern:
-Constant changes in intensity, duration and frequency (frequency 1-30 Hz, field strength 0,5-1,5 mT, 5-15 Gauss)
- The signals correspond with the natural physiological body signals
-They activate the self healing process of the body

Magnetix ArthroCare stimulates the chondrocytes.
Observation: more production of proteoglycan and collagen (building blocks for the extracellular matrix)

Magnetix ArthroCare stimulates the chondrocytes.

Observation: more production of proteoglycan and collagen (building blocks for the extracellular matrix)

The patent “electromagnetic stimulation of cartilage tissue” with original PST® (old brand name Magnetix ArthroCare) energy parameters was issued under
  • US patent number 6,524,233
  • European patent 1,119,393.
Inventor: Richard Markoll.
In fact, the Global Medical Device Nomenclature (GMDN) Agency has recognized PST® (old brand name Magnetix ArthroCare) as a unique technology and therefore created a new classification only for PST® products (GMDN GENERAL CODE 47584).

The patent “electromagnetic stimulation of cartilage tissue” with original PST® (old brand name Magnetix ArthroCare) energy parameters was issued under
  • US patent number 6,524,233
  • European patent 1,119,393.
Inventor: Richard Markoll.
In fact, the Global Medical Device Nomenclature (GMDN) Agency has recognized PST® (old brand name Magnetix ArthroCare) as a unique technology and therefore created a new classification only for PST® products (GMDN GENERAL CODE 47584).


Procedure

During a one-hour therapy session, the joint is treated in an enclosed coil.
A treatment course consists of 9-12 hourly sessions conducted on consecutive days.
If necessary, only one interruption of less than 2 days (48 hours) is authorized after completion of at least 3 treatment sessions.
Magnetix ArthroCare treatment is non-invasive, pain free and has no known side effects.
In addition to the treatment of osteoarthritis, Magnetix ArthroCare has been increasingly used as a therapy for injuries such as stress fractures and/or tendinopathies.
Magnetix ArthroCare has increasingly gained importance in the conservative therapy of professional and amateur athletes.

The working principle of the MagAC for joint pain technology
is scientifically founded

Joint at rest

Charge equilibrium between hydrogen protons and neg­ative charge carriers of the extracellular cartilage matrix (ECM)— no streaming voltage potential.

Joint under load

Generation of a streaming voltage potential in the joint under load by the "compression" of fluid forced out of cartilage tissue with forced movement displacement of the hydrogen protons (joint flexion).

Joint under Magnetix ArthroCare

Generation of streaming potential flow in the joint caused by forced movement of hydrogen protons in the extra-cellular cartilage matrix through alternating rectangular impulses as stimuli for the cells in the connective tissue, primarily chondrocytes.

The working principle of the MagAC for joint pain technology is scientifically founded

Joint at rest

Charge equilibrium between hydrogen protons and neg­ ative charge carriers of the extracellular cartilage matrix (ECM) — no streaming voltage potential.

Joint under load

Generation of a streaming voltage potential in the joint under load by the "compression" of fluid forced out of cartilage tissue with forced movement displacement of the hydrogen protons (joint flexion).

Joint under Magnetix ArthroCare

Generation of streaming potential flow in the joint caused by forced movement of hydrogen protons in the extra-cellular cartilage matrix through alternating rectangular impulses as stimuli for the cells in the connective tissue, primarily chondrocytes.

The Magnetix ArthroCare therapy concept supports natural processes and can be applied as a pain free, non invasive method without known side effects.

  •    Functions of electric currents

    The tissues of the human musculoskeletal system are stressed by continuous support of the body weight and muscle and tendon strength. The car­tilage tissue reacts with a functional adaptation. It has been demonstrated that the cartilage layer of the joints under higher load will become thicker and enable a more even distribution of the load. Electrical currents are responsible for the function of the cartilage cells and the regeneration of the bone tissue.

  •    What Magnetix ArthroCare does

    However, in unhealthy cartilage tissue a normal flow of streaming potentials is severely affected.

    The patented Original Magnetix ArthroCare technology intervenes here in the treatment of the affected joint cartilage. The unhealthy tissue is treated with impulses that constantly change in intensity and duration. Another effect of the pulsed electromagnetic fields method is that Magnetix ArthroCare stimulates the natural regeneration of the cartilage cells and the bone tissue with changing rectangular impulses.

  The Magnetix ArthroCare therapy
  concept supports
  natural processes and can be
  applied as a pain free,
  non invasive method without
  known side effects.
  •    Functions of electric

       currents

    The tissues of the human musculoskeletal system are stressed by continuous support of the body weight and muscle and tendon strength.

    The car­tilage tissue reacts with a functional adaptation. It has been demonstrated that the cartilage layer of the joints under higher load will become thicker and enable a more even distribution of the load. Electrical currents are responsible for the function of the cartilage cells and the regeneration of the bone tissue.

  •    What Magnetix

       ArthroCare does

    However, in unhealthy cartilage tissue a normal flow of streaming potentials is severely affected.

    The patented Original Magnetix ArthroCare technology intervenes here in the treatment of the affected joint cartilage. The unhealthy tissue is treated with impulses that constantly change in intensity and duration. Another effect of the pulsed electromagnetic fields method is that Magnetix ArthroCare stimulates the natural regeneration of the cartilage cells and the bone tissue with changing rectangular impulses.

How does Magnetix ArthroCare work? (extract)

Various studies indicate that the capacity of the cartilaginous tissue to withstand compressive stresses is linked to the level of proteoglycans in the intercellular substance; the sulphated glycosaminoglycan chains have an increased concentration of negative electrical charges which give considerable rigidity to the system by their reciprocal repulsion and hold bound a large part of the cartilaginous water in states of rest.
How does Magnetix ArthroCare work? (extract)

Various studies indicate that the capacity of the cartilaginous tissue to withstand compressive stresses is linked to the level of proteoglycans in the intercellular substance; the sulphated glycosaminoglycan chains have an increased concentration of negative electrical charges which give considerable rigidity to the system by their reciprocal repulsion and hold bound a large part of the cartilaginous water in states of rest.

Dynamic Balance in Cartilage: Chondrocyte Response to Degeneration and Attempted Regeneration

Dynamic Balance in Cartilage: Chondrocyte Response to Degeneration and Attempted Regeneration

Once the destructive process has begun, similarly to the operation of factors which stimulate the chondrocytes to produce harmful substance in pathological quantities, the same cells initiate an attempt at regeneration of the cartilage by increasing the synthesis of glycosaminoglycans.

However, they are not capable of supporting such hyperactivity for long, so the glycosaminoglycan content is reduced with a more marked reduction in the chondroitin sulphates and an increase in the keratan sulphate/chondroitin sulphate ratio.

The reduction in the proteoglycans, the breaking up of the proteoglycan aggregates, their increased extractability and the change in tissue hydration cause a reduction of the resistance of the amorphous substance and the collagen fibrils are subjected to intolerable mechanical pressure.

There have been numerous studies showing that the process is reversible initially; if maintenance of an adequate concentration of GAG is successful, the cartilage damage can be hindered or slowed and use of chondroprotective drugs and also of MagAC is based on this assumption.
Once the destructive process has begun, similarly to the operation of factors which stimulate the chondrocytes to produce harmful substance in pathological quantities, the same cells initiate an attempt at regeneration of the cartilage by increasing the synthesis of glycosaminoglycans.

However, they are not capable of supporting such hyperactivity for long, so the glycosaminoglycan content is reduced with a more marked reduction in the chondroitin sulphates and an increase in the keratan sulphate/chondroitin sulphate ratio.
The reduction in the proteoglycans, the breaking up of the proteoglycan aggregates, their increased extractability and the change in tissue hydration cause a reduction of the resistance of the amorphous substance and the collagen fibrils are subjected to intolerable mechanical pressure.

There have been numerous studies showing that the process is reversible initially; if maintenance of an adequate concentration of GAG is successful, the cartilage damage can be hindered or slowed and use of chondroprotective drugs and also of MagAC is based on this assumption.

Magnetix ArthroCare: Revolutionary Therapy for Cartilage and Soft Tissue Treatment

Magnetix ArthroCare is based on a patent developed by the American doctor and biophysicist of German origin, Richard Markoll.
This is a therapeutic method which differs from the so-called magnetic field therapy used for many years for slowly consolidating fractures.
Magnetix ArthroCare, while it can be used in bone tissue also, finds its main indication in the treatment of cartilage and of soft and connective tissues.
To understand the effect of Magnetix ArthroCare, it must be remembered that when a joint is subjected to compressive stress, there is a displacement of the water present in the matrix accompanied by sodiumions, leaving the negative charges of the proteoglycan molecules unneutralised.

Magnetix ArthroCare:

Revolutionary Therapy

for Cartilage and

Soft Tissue Treatment

Magnetix ArthroCare is based on a patent developed by the American doctor and biophysicist of German origin, Richard Markoll.
This is a therapeutic method which differs from the so-called magnetic field therapy used for many years for slowly consolidating fractures.
Magnetix ArthroCare, while it can be used in bone tissue also, finds its main indication in the treatment of cartilage and of soft and connective tissues.
To understand the effect of Magnetix ArthroCare, it must be remembered that when a joint is subjected to compressive stress, there is a displacement of the water present in the matrix accompanied by sodiumions, leaving the negative charges of the proteoglycan molecules unneutralised.

The mechanical-electrical transduction.

By a mechanism of mechanical-electrical transduction, the mechanical stimulus is transformed into a weak electric current (potential streaming) which is thought to represent the main signal for the cartilage cells to increase the synthesis of proteoglycans and collagen.
The mechanical-electrical transduction.

By a mechanism of mechanical-electrical transduction, the mechanical stimulus is transformed into a weak electric current (potential streaming) which is thought to represent the main signal for the cartilage cells to increase the synthesis of proteoglycans and collagen.

Supported by clinical studies and laboratory research.


If the potential streaming is the signal for chondrocytes to produce new matrix, the same effect can be obtained by exposing the joint to an electromagnetic field, producing currents which simulate those of the organism. Administration in this way of low strength pulsed signals at a frequency similar to the biological one is capable of creating an electrical field in the joint, promoting the regeneration of the cartilaginous tissue, and thus conferring physical chondroprotection.

Supported by clinical studies and laboratory research.


If the potential streaming is the signal for chondrocytes to produce new matrix, the same effect can be obtained by exposing the joint to an electromagnetic field, producing currents which simulate those of the organism. Administration in this way of low strength pulsed signals at a frequency similar to the biological one is capable of creating an electrical field in the joint, promoting the regeneration of the cartilaginous tissue, and thus conferring physical chondroprotection.
  •    Enhanced

       Joint Function and Healing

    Early improvement of the joint function (mobility and flexibility) by the removal of muscular tension, with normalized joint kinematics and reduced pain.


    Stimulation of the chondrocyte activity on streaming potentials with regeneration of the cartilage tissue

  •    Multifaceted Benefits of

       a Therapeutic Approach

    Acceleration of the healing process in injuries to joint-related structures


    Stimulation of the osteoblast activ­ity through piezoelectric potentials with stabilisation of the bone thick­ness

  •    Enhanced Joint

       Function and Healing

    Early improvement of the joint function (mobility and flexibility) by the removal of muscular tension, with normalized joint kinematics and reduced pain.


    Stimulation of the chondrocyte activity on streaming potentials with regeneration of the cartilage tissue

  •   Multifaceted Benefits

      of a Therapeutic

      Approach

    Acceleration of the healing process in injuries to joint-related structures


    Stimulation of the osteoblast activ­ity through piezoelectric potentials with stabilisation of the bone thick­ness


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